Title of article
Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors
Author/Authors
Irini Akritopoulou-Zanze، نويسنده , , Daria Darczak، نويسنده , , Kathy Sarris، نويسنده , , Kathleen M. Phelan، نويسنده , , Jeffrey R. Huth، نويسنده , , Danying Song، نويسنده , , Eric F. Johnson، نويسنده , , Yong Jia، نويسنده , , Stevan W. Djuric، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
96
To page
99
Abstract
We report the synthesis of kinase targeted libraries based on the thienopyrazole scaffold. Several thienopyrazole analogs have been identified as submicromolar inhibitors of KDR.
Keywords
Kinase inhibitors , Thienopyrazoles , Targeted libraries , KDR inhibitors , De novo design
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796321
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