Title of article
New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists
Author/Authors
Maria Zappalà، نويسنده , , Alessia Pellican?، نويسنده , , Nicola Micale، نويسنده , , Frank S. Menniti، نويسنده , , Guido Ferreri، نويسنده , , Giovambattista De Sarro، نويسنده , , Silvana Grasso، نويسنده , , Carlo De Micheli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
167
To page
170
Abstract
A series of 1-aryl-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-ones 2a–f, were synthesized and screened as anticonvulsant agents in DBA/2 mice against sound-induced seizures. The new compounds display anticonvulsant properties although the ED50 values are higher than those of prototypes 1-aryl-3,5-dihydro-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (1) and GYKI 52466, well-known noncompetitive AMPA receptor antagonists. Functional tests were performed to evaluate the antagonistic activity at the AMPA and kainate receptors.
Keywords
3 , 5-Dihydro-7 , 8-ethylenedioxy-4H-2 , 3-benzodiazepin-4-ones , anticonvulsant activity , AMPA receptor antagonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796337
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