Title of article
Optimization of CCR4 antagonists: Side-chain exploration
Author/Authors
Ashok V. Purandare، نويسنده , , Honghe Wan، نويسنده , , Aiming Gao، نويسنده , , John Somerville، نويسنده , , Christine Burke، نويسنده , , Wayne Vaccaro، نويسنده , , Xiaoxia Yang، نويسنده , , Kim W. McIntyre، نويسنده , , Michael A. Poss، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
204
To page
207
Abstract
The design, synthesis, and activity of novel and selective small molecule antagonists of the CC chemokine receptor-4 (CCR4) are presented. Compound 8c was efficacious in a murine allergic inflammation model (ED50 30 mg/kg).
Keywords
Chemokine receptor CCR4 , Antagonist , mDC , In vivo active , asthma
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796345
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