Title of article
Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation
Author/Authors
Suresh Awale، نويسنده , , Eduardo M.N. Nakashima، نويسنده , , Surya K. Kalauni، نويسنده , , Yasuhiro Tezuka، نويسنده , , Yukiko Kurashima، نويسنده , , Jie Lu، نويسنده , , Hiroyasu Esumi، نويسنده , , Shigetoshi Kadota، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
581
To page
583
Abstract
The CH2Cl2-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 μg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 μg/ml.
Keywords
PANC-1 , Screening strategy , Anti-austerity , Angelica pubescens , Anti-cancer agent , Angelmarin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796419
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