Title of article
Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors
Author/Authors
Ji-Feng Liu، نويسنده , , Christopher J. Wilson، نويسنده , , Lie-ping Ye، نويسنده , , Kevin Sprague، نويسنده , , Katie Sargent، نويسنده , , Ying Si، نويسنده , , Galina Beletsky، نويسنده , , Daniel Yohannes، نويسنده , , Shi-Chung Ng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
686
To page
690
Abstract
A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.
Keywords
Privileged structure , Quinazolinone , Tubulin polymerization inhibitors , Natural product-templated library
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796441
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