• Title of article

    Derivatives of tramadol for increased duration of effect

  • Author/Authors

    Liming Shao، نويسنده , , Craig Abolin، نويسنده , , Michael C. Hewitt، نويسنده , , Patrick Koch، نويسنده , , Mark Varney، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2006
  • Pages
    4
  • From page
    691
  • To page
    694
  • Abstract
    Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. Analogs of tramadol with deuterium-for-hydrogen replacement at metabolically active sites were prepared and evaluated in vitro and in vivo.
  • Keywords
    Tramadol , Metabolic stability , Deuterium isotope effect , opioids
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2006
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    796442

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=796442