Title of article
Expedited SAR study of high-affinity ligands to the α2δ subunit of voltage-gated calcium channels: Generation of a focused library using a solution-phase Sn2Ar coupling methodology
Author/Authors
Chixu Chen، نويسنده , , Brian Stearns، نويسنده , , Tao Hu، نويسنده , , Naomi Anker، نويسنده , , Angelina Santini، نويسنده , , Jeannie M. Arruda، نويسنده , , Brian T. Campbell، نويسنده , , Purabi Datta، نويسنده , , Jayashree Aiyar، نويسنده , , Benitio Munoz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
746
To page
749
Abstract
The SAR of the lead compound 3, a novel ligand for the α2δ subunit of voltage-gated calcium channels, was rapidly explored. Utilizing a parallel solution-phase Sn2Ar coupling approach, a focused library was obtained. The library was evaluated in vitro and afforded a series of analogues with improved potencies. The SAR trends of the library are also described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796454
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