Title of article
Discovery of a potent phenolic N1-benzylidene–pyridinecarboxamidrazone selective against Gram-positive bacteria
Author/Authors
Daniel L. Rathbone، نويسنده , , Katy J. Parker، نويسنده , , Michael D. Coleman، نويسنده , , Peter A. Lambert، نويسنده , , David C. Billington، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
879
To page
883
Abstract
As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene–pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria.
Keywords
Carboxamidrazone , MRSA , antimicrobial
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796481
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