Title of article
Aplysamine-1 and related analogs as histamine H3 receptor antagonists
Author/Authors
Devin M. Swanson، نويسنده , , Sandy J. Wilson، نويسنده , , Jamin D. Boggs، نويسنده , , Wei Xiao، نويسنده , , Richard Apodaca، نويسنده , , Ann J. Barbier، نويسنده , , Timothy W. Lovenberg، نويسنده , , Nicholas I. Carruthers، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
897
To page
900
Abstract
Aplysamine-1 (1), a marine natural product, was synthesized and screened for in vitro activity at the human and rat histamine H3 receptors. Aplysamine-1 (1) was found to possess a high binding affinity for the human H3 receptor (Ki = 30 ± 4 nM). Synthetic analogs of 1, including des-bromoaplysamine-1 (10) and dimethyl-{2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-ethyl}-amine (13), were potent H3 antagonists.
Keywords
H3 ligand , marine natural product , histamine , Histamine H3 receptor , Aplysamine-1 , Histamine H3 receptor antagonists , Neurotransmitter
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796485
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