Stimulation on DNA triplet repeat strand slippage synthesis by the designed spirocycles

The designed simpler chiral spirocyclic helical compounds that mimic the molecular architecture of the DNA bulge binder NCSi-gb have been prepared. It has been found that the synthesized spirocyclic compounds have strong stimulation effect on DNA slippage synthesis. Their stimulation activities on DNA strand slippage suggest that they may bind to or induce the formation of a non Watson–Crick structure during in vitro replication of DNA triplet repeats.