Title of article
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents
Author/Authors
Julieta Coro، نويسنده , , Richard Atherton، نويسنده , , Susan Little، نويسنده , , Hayley Wharton، نويسنده , , Vanessa Yardley، نويسنده , , Amaury Alvarez Jr.، نويسنده , , Margarita S?arez، نويسنده , , Rolando Pérez، نويسنده , , Hortensia Rodr?guez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1312
To page
1315
Abstract
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC50 values ranging between 0.3 and 4 μM for the most active compounds.
Keywords
Alkyl-linked bis-THTT anti-protozoal activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796567
Link To Document