Title of article
New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity
Author/Authors
Sergio A. Alonso De Diego، نويسنده , , Marta Gutiérrez-Rodr?guez، نويسنده , , M. Jes?s Pérez de Vega، نويسنده , , Diego Casabona، نويسنده , , Carlos Cativiela، نويسنده , , Rosario Gonz?lez-Mu?iz، نويسنده , , Rosario Herranz، نويسنده , , Edurne Cenarruzabeitia، نويسنده , , Diana Frechilla، نويسنده , , Joaqu?n Del R?o، نويسنده , , M. Luisa Jimeno، نويسنده , , M. Teresa Garc?a-L?pez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1392
To page
1396
Abstract
A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
Keywords
GPE analogues , solid-phase synthesis , Neuroprotective activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796585
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