Title of article
Protein tyrosine phosphatase 1B inhibitors from Morus root bark
Author/Authors
Long Cui، نويسنده , , MinKyun Na، نويسنده , , Hyuncheol Oh، نويسنده , , Eun Young Bae، نويسنده , , Dae Gwin Jeong، نويسنده , , Seong-Eon Ryu، نويسنده , , Sohee Kim، نويسنده , , Bo Yeon Kim، نويسنده , , Won Keun Oh، نويسنده , , Jong Seog Ahn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1426
To page
1429
Abstract
An organic layer prepared from the Chinese crude drug ‘Sang-Bai-Pi’ (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin O (5) and moracin P (6). Compounds 1–4 inhibited PTP1B with IC50 values ranging from 1.6 ± 0.3 μM to 16.9 ± 1.1 μM.
Keywords
Morus root bark , Protein tyrosine phosphatase 1B , Sanggenon C , Sanggenon G , Kuwanon L , Mulberrofuran C
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796593
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