Title of article
Synthesis and biological investigation of new 4″-malonyl tethered derivatives of erythromycin and clarithromycin
Author/Authors
Daniel Sherman، نويسنده , , Liqun Xiong، نويسنده , , Alexander S. Mankin، نويسنده , , Artem Melman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1506
To page
1509
Abstract
A new approach to 4″-substituted derivatives of erythromycin and clarithromycin was developed by converting them into corresponding 4″-malonic monoesters. Subsequent carbodiimide coupling with alcohols and amines provided new macrolide derivatives that are capable of binding to 50S ribosomal subunits and inhibiting protein synthesis in cell-free system.
Keywords
Macrolides , ribosome , antibiotics , tethering
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796608
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