Title of article
Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents
Author/Authors
Jayendra Patole، نويسنده , , Dipti Shingnapurkar، نويسنده , , Subhash Padhye، نويسنده , , Colin Ratledge and Roland K. Strong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1514
To page
1517
Abstract
Schiff base conjugates of p-aminosalicylic acid have been synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy and cyclic voltammetry. Compounds containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher Clog P values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities.
Keywords
para-Amino salicyclic acid , Mycobacterium bovis , Antimycobacterial agents
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796610
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