Title of article
Synthesis of the first sulfur-35-labeled hERG radioligand
Author/Authors
Conrad E. Raab، نويسنده , , John W. Butcher، نويسنده , , Thomas M. Connolly، نويسنده , , Jerzy Karczewski، نويسنده , , Nathan X. Yu، نويسنده , , Steven J. Staskiewicz، نويسنده , , Nigel Liverton، نويسنده , , Dennis C. Dean، نويسنده , , David G. Melillo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1692
To page
1695
Abstract
The synthesis of the first high specific activity S-35-labeled hERG radioligand, [35S]MK-0499, for use in HTS assays of drug candidates for hERG interaction is described. The radioligand is prepared by [35S]sulfonylation of a high diastereomeric excess (de) aniline precursor prepared from unlabeled MK-0499.
Keywords
S-35 , synthesis , HERG , Radioligand
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796646
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