Title of article
Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2
Author/Authors
Xiaoyan Zhang، نويسنده , , Maud Urbanski، نويسنده , , Mona Patel، نويسنده , , Geoffrey G. Cox، نويسنده , , Roxanne E. Zeck، نويسنده , , Haiyan Bian، نويسنده , , Bruce R. Conway، نويسنده , , Mary Pat Beavers، نويسنده , , Philip J. Rybczynski، نويسنده , , Keith T. Demarest، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
1696
To page
1701
Abstract
A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats.
Keywords
SGLT , glucosides
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796647
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