Title of article
Isoquinoline derivatives as potential acetylcholinesterase inhibitors
Author/Authors
Sutthatip Markmee، نويسنده , , Somsak Ruchirawat، نويسنده , , Vilailak Prachyawarakorn، نويسنده , , Kornkanok Ingkaninan، نويسنده , , Nantaka Khorana، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
2170
To page
2172
Abstract
Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.
Keywords
Acetylcholinesterase inhibitors , Alzheimer’s disease , Isoquinoline
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796743
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