Title of article
Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant
Author/Authors
Ester Muraglia، نويسنده , , Olaf D. Kinzel، نويسنده , , Ralph Laufer، نويسنده , , Michael D. Miller، نويسنده , , Gregory Moyer، نويسنده , , Vandna Munshi، نويسنده , , Federica Orvieto، نويسنده , , Maria Cecilia Palumbi، نويسنده , , Giovanna Pescatore، نويسنده , , Michael Rowley، نويسنده , , Peter D. Williams، نويسنده , , Vincenzo Summa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2748
To page
2752
Abstract
A series of aryltetrazolylacetanilides was synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors on wild-type virus and on the clinically relevant K103N mutant strain. Extensive SAR investigation led to potent compounds, with nanomolar activity on K103N, and orally bioavailable in rats.
Keywords
Non-nucleoside reverse transcriptase inhibitors , Tetrazole thioacetanilides , HIV
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796861
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