Title of article
Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors
Author/Authors
Hiroko Sano، نويسنده , , Tomomi Noguchi، نويسنده , , Atsushi Miyajima، نويسنده , , Yuichi Hashimoto، نويسنده , , Hiroyuki Miyachi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3068
To page
3072
Abstract
Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).
Keywords
Angiogenesis , COX-1 , Cox-1 inhibitor , HUVEC
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796929
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