Title of article
3,4-Fused cyclohexyl sulfones as γ-secretase inhibitors
Author/Authors
Duncan Shaw، نويسنده , , Jonathan Best، نويسنده , , Kevin Dinnell، نويسنده , , Alan Nadin، نويسنده , , Mark Shearman، نويسنده , , Christine Pattison، نويسنده , , James Peachey، نويسنده , , Michael Reilly، نويسنده , , Brian Williams، نويسنده , , Jonathan Wrigley، نويسنده , , Timothy Harrison، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3073
To page
3077
Abstract
The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent γ-secretase inhibitors. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain Aβ in transgenic mouse models and thus have potential as possible treatments for Alzheimer’s disease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796930
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