Title of article
Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors
Author/Authors
Yue Mei Zhang، نويسنده , , Xiaodong Fan، نويسنده , , Bangping Xiang، نويسنده , , Devraj Chakravarty، نويسنده , , Robert Scannevin، نويسنده , , Sharon Burke، نويسنده , , Prabha Karnachi، نويسنده , , Kenneth Rhodes، نويسنده , , Paul Jackson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3096
To page
3100
Abstract
A series of novel carboxylic acid-based α-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR is discussed. A potential binding mode in the active site of the MMP-9 homology model was highlighted. These compounds are potent MMP-9 inhibitors and are selective over MMP-1.
Keywords
MMP-2 , ?-sulfonylcarboxylic acids , MMP inhibitors , MMP-9
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796933
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