Title of article
Identification of novel PPARα ligands by the structural modification of a PPARγ ligand
Author/Authors
Shinya Usui، نويسنده , , Hiroki Fujieda، نويسنده , , Takayoshi Suzuki، نويسنده , , Naoaki Yoshida، نويسنده , , Hidehiko Nakagawa، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3249
To page
3254
Abstract
To develop novel PPARα ligands, we designed and synthesized several 3-{3-[2-(nonylpyridin-2-ylamino)ethoxy]phenyl}propanoic acid derivatives. Compound 10, the meta isomer of a PPARγ agonist 1, has been identified as a PPARα ligand. The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPARα-binding potency.
Keywords
Peroxisome proliferator-activated receptor , PPAR? ligand , PPAR? ligand , Nuclear receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796967
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