Title of article
Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease
Author/Authors
Tan Siew Kiat، نويسنده , , Richard Pippen، نويسنده , , Rohana Yusof، نويسنده , , Halijah Ibrahim، نويسنده , , and Norzulaani Khalid، نويسنده , , Noorsaadah Abd Rahman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3337
To page
3340
Abstract
Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 μM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.
Keywords
Cyclohexenyl chalcone derivatives , Dengue 2 , NS3 protease , Competitive inhibitory activities , Boesenbergia rotunda (L.) extracts
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796986
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