Title of article
Nε-Thioacetyl-lysine: A multi-facet functional probe for enzymatic protein lysine Nε-deacetylation
Author/Authors
David G. Fatkins، نويسنده , , Andrew D. Monnot، نويسنده , , Weiping Zheng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3651
To page
3656
Abstract
Peptides containing Nε-thioacetyl-lysine and Nε-acetyl-lysine were evaluated for their de(thio)acetylation catalyzed by human HDAC8 and SIRT1, two distinct protein deacetylases. Nε-Thioacetyl-lysine was found to be a mimic of Nε-acetyl-lysine for HDAC8-catalyzed reaction, but to confer inhibition against SIRT1. These results point to further diverse applications based on Nε-thioacetyl-lysine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797050
Link To Document