Title of article
Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP)
Author/Authors
Qi Sun، نويسنده , , Run-Tao Li، نويسنده , , Wei Guo، نويسنده , , Jing-Rong Cui، نويسنده , , Tie-Ming Cheng، نويسنده , , Ze-Mei Ge، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3727
To page
3730
Abstract
A novel class of cyclophosphamide spiropiperaziniums was synthesized and evaluated for their in vivo anti-cancer activities against S180 and H22. Most of them exhibited definite activities. Especially, compounds 8b and 8k showed good anti-cancer activities, meanwhile, 8k also showed much lower toxicity than CP. Several interesting structure–activity relationships were revealed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797065
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