Title of article
3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors
Author/Authors
Christopher M. McBride، نويسنده , , Paul A. Renhowe، نويسنده , , Thomas G. Gesner، نويسنده , , Johanna M. Jansen، نويسنده , , Julie Lin، نويسنده , , Sylvia Ma، نويسنده , , Yasheen Zhou، نويسنده , , Cynthia M. Shafer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3789
To page
3792
Abstract
The 3-benzimidazol-2-yl-1H-indazole scaffold was developed as an alternate scaffold for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, it was discovered that a subset of these compounds potently inhibit the enzyme c-ABL. The SAR of these compounds is described.
Keywords
Indazole , Benzimidazole , Protein tyrosine kinase , c-Abl , Chronic myelogenous leukemia (CML)
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797079
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