Title of article
Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates
Author/Authors
Yasuko Takahashi، نويسنده , , Haruhiko Fuwa، نويسنده , , Akane Kaneko، نويسنده , , Makoto Sasaki، نويسنده , , Satoshi Yokoshima، نويسنده , , Hifumi Koizumi، نويسنده , , Tohru Takebe، نويسنده , , Toshiyuki Kan، نويسنده , , Takeshi Iwatsubo، نويسنده , , Taisuke Tomita، نويسنده , , Hideaki Natsugari، نويسنده , , Tohru Fukuyama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3813
To page
3816
Abstract
Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel γ-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arranged on the core six-membered ring. Structure–activity relationship studies of these compounds were also developed.
Keywords
?-Secretase , inhibitor , Structure–activity relationships , Cyclohexenone
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797085
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