Title of article
Synthesis of [11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase
Author/Authors
Ji-Quan Wang، نويسنده , , Mingzhang Gao، نويسنده , , Kathy D. Miller، نويسنده , , George W. Sledge Jr، نويسنده , , Qi-Huang Zheng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4102
To page
4106
Abstract
Iressa (Gefitinib) is an orally active inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR-TK) involved in cell signal transduction processes critical to proliferation, apoptosis, repair, and angiogenesis of cancer cells. [11C]Iressa was first designed and synthesized as a new potential positron emission tomography (PET) cancer imaging agent for EGFR-TK in 30–40% radiochemical yield with 4.0–6.0 Ci/μmol specific activity at end of bombardment (EOB).
Keywords
Iressa , Positron emission tomography (PET) , Carbon-11 , Cancer imaging , Epidermal growth factor receptor tyrosine kinase (EGFR-TK)
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797144
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