• Title of article

    Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5

  • Author/Authors

    Fujiko Takamura، نويسنده , , Akira Tanaka، نويسنده , , Hisashi Takasugi، نويسنده , , Kiyoshi Taniguchi، نويسنده , , Mie Nishio، نويسنده , , Jiro Seki، نويسنده , , Kouji Hattori، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2006
  • Pages
    4
  • From page
    4475
  • To page
    4478
  • Abstract
    A metabolism study of FK788 (2) led to the discovery of new diphenylcarbamoyl derivatives as prostacyclin mimetics without the PG skeleton. We designed and evaluated PGI2 mimetics based on blocking the main metabolic pathway of FK788. The new compound 7c was found to be equipotent to FK788 towards PGI2 agonist activity and metabolically more stable than FK788.
  • Keywords
    Prostacyclin , FK788 , PG , PGI2 , metabolism
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2006
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797212

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797212