Title of article
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide
Author/Authors
Tomonori Yanagawa، نويسنده , , Tomomi Noguchi، نويسنده , , Hiroyuki Miyachi، نويسنده , , Hisayoshi Kobayashi، نويسنده , , Yuichi Hashimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
4748
To page
4751
Abstract
4,7-Difluoro-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [4,7FPP-33 (14)] has a potent tubulin-polymerization-inhibiting activity comparable with those of the known tubulin-polymerization inhibitors rhizoxin and colchicine. The structure–activity relationship for fluorine substitution was elucidated.
Keywords
Fluorophthalimide , thalidomide , Tubulin polymerization inhibitor , Tubulin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797268
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