• Title of article

    Exploring alternative Zn-binding groups in the design of HDAC inhibitors: Squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA

  • Author/Authors

    Stephen Hanessian، نويسنده , , Valerio Vinci، نويسنده , , Luciana Auzzas، نويسنده , , Mauro Marzi، نويسنده , , Giuseppe Giannini، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2006
  • Pages
    4
  • From page
    4784
  • To page
    4787
  • Abstract
    Analogues of suberoylanilide hydroxamic acid (SAHA) were prepared by replacing the Zn-binding group with squaric acid, N-hydroxyurea, and 4-hydroxymethyl oxazoline units, also varying the length of the aliphatic chain. No inhibitory activity on HDAC was observed below 1.0 μM and no cytotoxic activity on different tumor cell lines was seen below 20.0 μM.
  • Keywords
    Metalloprotease inhibitor
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2006
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797277

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797277