Title of article
Propionylpiperazines as human melanocortin-4 receptor ligands
Author/Authors
Caroline W. Chen، نويسنده , , Joe A. Tran، نويسنده , , Wanlong Jiang، نويسنده , , Fabio C. Tucci، نويسنده , , Melissa Arellano، نويسنده , , Jenny Wen، نويسنده , , Beth A. Fleck، نويسنده , , Dragan Marinkovic، نويسنده , , Nicole S. White، نويسنده , , Joseph Pontillo، نويسنده , , John Saunders، نويسنده , , Ajay Madan، نويسنده , , Alan C. Foster، نويسنده , , Chen Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
4800
To page
4803
Abstract
A series of α-benzylpropionylpiperazines were synthesized and tested as antagonists of the melanocortin-4 receptor. In addition to its high potency and selectivity, R-11a had desirable pharmacokinetic properties including high brain penetration in mice.
Keywords
Propionylpiperazine , melanocortin-4 receptor , Antagonist , pharmacokinetic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797281
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