• Title of article

    Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors

  • Author/Authors

    Hui Li، نويسنده , , John Tatlock، نويسنده , , M. Angelica Linton، نويسنده , , Javier Gonzalez، نويسنده , , Allen Borchardt، نويسنده , , Peter Dragovich، نويسنده , , Tanya Jewell، نويسنده , , Tom Prins، نويسنده , , Ru Zhou، نويسنده , , Julie Blazel، نويسنده , , Hans Parge، نويسنده , , Robert Love، نويسنده , , Michael Hickey، نويسنده , , Chau Doan، نويسنده , , Stephanie Shi، نويسنده , , Rohit Duggal، نويسنده , , Cristina Lewis، نويسنده , , Shella Fuhrman، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2006
  • Pages
    5
  • From page
    4834
  • To page
    4838
  • Abstract
    A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Herein we report the structure–activity relationships (SARs) of this novel class of dihydropyrone-containing compounds that show potent inhibitory activities against the HCV RNA polymerase in biochemical assays.
  • Keywords
    HCV Polymerase , Dihydropyrone , structure-based drug design
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2006
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797289

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797289