Title of article
Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo
Author/Authors
Jeffrey R. Spencer، نويسنده , , Martin Sendzik، نويسنده , , Jason Oeh، نويسنده , , Peter Sabbatini، نويسنده , , Stacie A. Dalrymple، نويسنده , , Catherine Magill، نويسنده , , Hyunjin M. Kim، نويسنده , , Penglie Zhang، نويسنده , , Neil Squires، نويسنده , , Katherine G. Moss، نويسنده , , Juthamas Sukbuntherng، نويسنده , , Doris Graupe، نويسنده , , John Eksterowicz، نويسنده , , Peter R. Young، نويسنده , , Andrew G. Myers، نويسنده , , Michael J. Green، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4884
To page
4888
Abstract
Novel analogs of (−)-saframycin A are described. The analogs are shown to be potent inhibitors of the in vitro growth of several tumor cells in a broad panel and promising as leads for further optimization. The first in vivo studies in a solid tumor model (HCT-116) reveal potent antitumor activity with associated toxicity of daily administration.
Keywords
Saframycin analog , GI50 , DNA binding , fluorescence , In vivo model
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797299
Link To Document