Title of article
Tetrahydroisoquinolines as MCH-R1 antagonists
Author/Authors
T.K. Sasikumar، نويسنده , , L. Qiang، نويسنده , , W.-L. Wu، نويسنده , , D.A. Burnett، نويسنده , , W.J. Greenlee، نويسنده , , K. O’Neill، نويسنده , , B.E. Hawes، نويسنده , , M. van Heek، نويسنده , , M. Graziano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4917
To page
4921
Abstract
A series of potent and selective inhibitors of h-MCH-R1 has been developed based on the piperidine glycineamide compounds I and II. These structurally more rigid tetrahydroisoquinolines (III and IV) showed better pharmacokinetics. The highly potent compounds 12d and 12g displayed excellent rat pk.
Keywords
Melanin concentrating hormone , Tetrahydroisoquinolines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797305
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