Title of article
Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties
Author/Authors
Peng Zhou، نويسنده , , Anca Dragulescu-Andrasi، نويسنده , , Birendra Bhattacharya، نويسنده , , Heather O’Keefe، نويسنده , , Paolo Vatta، نويسنده , , Jens J. Hyldig-Nielsen، نويسنده , , Danith H. Ly، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4931
To page
4935
Abstract
Guanidine-based peptide nucleic acid (GPNA) monomers and oligomers containing all four natural (adenine (A), cytosine (C), guanine (G), and thymine (T)) and two unnatural (2-thiouracil (sU) and 2,6-diaminopurine (D)) nucleobases have been synthesized. Thermal denaturation study showed that GPNA oligomers containing alternate D-backbone configuration bind sequence-specifically to DNA and, when incubated with mammalian cells, localized specifically to the endoplasmic reticulum (ER).
Keywords
Cell-permeable , Monomers , GPNA , Guanidine-based peptide nucleic acid , Oligomers , Endoplasmic reticulum , synthesis , ER
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797307
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