Title of article
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones (‘quinols’)
Author/Authors
Cedric J. Lion، نويسنده , , Charles S. Matthews، نويسنده , , Geoffrey Wells، نويسنده , , Tracey D. Bradshaw، نويسنده , , Malcolm F.G. Stevens، نويسنده , , Andrew D. Westwell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5005
To page
5008
Abstract
The synthesis and in vitro antitumour evaluation of a new series of fluorinated benzothiazole-substituted 4-hydroxycyclohexa-2,5-dienones (‘quinols’) is described. The new compounds were found to be of comparable activity compared to the non-fluorinated precursor PMX 464, in terms of antiproliferative activity in sensitive human cancer cell lines (nanomolar GI50 values) and inhibitory activity against the thioredoxin signalling system.
Keywords
antitumour agents , Fluorinated benzothiazoles , thioredoxin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797318
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