Title of article
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters
Author/Authors
Guangrong Zheng، نويسنده , , David B. Horton، نويسنده , , Agripina G. Deaciuc، نويسنده , , Linda P. Dwoskin، نويسنده , , Peter A. Crooks، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5018
To page
5021
Abstract
A series of des-keto lobeline analogs has been synthesized and evaluated for their ability to inhibit the dopamine transporter (DAT) and serotonin transporter (SERT) function and for their affinity for the synaptic vesicle monoamine transporter (VMAT2), as well as for α4β2* and α7* neuronal nicotinic acetylcholine receptors (nAChRs). The enantiomers 8R-hydroxylobel-9-ene (3a) and 10S-hydroxylobel-7-ene (3c) exhibited high potency and selectivity at SERT and DAT, respectively.
Keywords
Vesicular monoamine transporter , Lobeline , Serotonin transporter , Dopamine transporter
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797321
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