Title of article
A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives
Author/Authors
Maria-Carmen Fernandez، نويسنده , , Ana Casta?o، نويسنده , , Esteban Dominguez، نويسنده , , Ana Escribano، نويسنده , , Delu Jiang، نويسنده , , Alma Jimenez، نويسنده , , Eric Hong، نويسنده , , William J. Hornback، نويسنده , , Eric S. Nisenbaum، نويسنده , , Nancy Rankl، نويسنده , , Eric Tromiczak، نويسنده , , Grant Vaught، نويسنده , , Hamideh Zarrinmayeh، نويسنده , , Dennis M. Zimmerman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5057
To page
5061
Abstract
The synthesis and initial SAR studies of novel, highly potent positive allosteric modulators of AMPA receptors based on 3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid (6a) are described. SAR studies at the thioether moiety indicated that substitution at this position was mandatory and better potency was achieved with small groups.
Keywords
AMPA receptor allosteric modulators , Heteroaryl carboxylic acids
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797329
Link To Document