Title of article
Ureas with histamine H3-antagonist receptor activity—A new scaffold discovered by lead-hopping from cinnamic acid amides
Author/Authors
Jesper F. Lau، نويسنده , , Claus Bekker Jeppesen، نويسنده , , Karin Rimvall، نويسنده , , Rolf Hohlweg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
5303
To page
5308
Abstract
A group of tri and tetrasubstituted urea derivatives have been found to be hH3-antagonists. The most potent compounds were found in the class of (piperazine-1-yl)-(piperidine-1-yl)-methanones which in addition showed negligible hERG inhibition.
Keywords
hH3-receptor , HERG , urea , Histamine H3 receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797375
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