Title of article
Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata
Author/Authors
Ki Hun Park، نويسنده , , Yong-Dae Park، نويسنده , , Jongmin Han، نويسنده , , Kyung-Ran Im، نويسنده , , Byong Won Lee، نويسنده , , Il Yun Jeong، نويسنده , , Tae-Sook Jeong، نويسنده , , Woo Song Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5580
To page
5583
Abstract
The catecholic xanthones and flavonoids 1–13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3–8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10–12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.
Keywords
LDL-antioxidant , RAW264.7 cells , ACAT inhibitor , nitric oxide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797432
Link To Document