Title of article
A homology model of SERT based on the LeuTAa template
Author/Authors
Aina Westrheim Ravna، نويسنده , , Malgorzata Jaronczyk، نويسنده , , Ingebrigt Sylte، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5594
To page
5597
Abstract
A human serotonin transporter (SERT) model has been constructed based on the crystal structure of the bacterial homologue of Na+/Cl−-dependent neurotransmitter transporters from Aquifex aeolicus (LeuTAa). Amino acids in the ligand binding area predicted by ICM pocket finder included Tyr95, Ala96, Asp98, Gly100 (transmembrane helix (TMH) 1), Ala169, Ile172, Ala173, Tyr176 (TMH3), Phe335, Ser336, Gly338, Phe341, Val343 (TMH6), Thr439, Ala441, and Gly442 (TMH8). The present model is an updated working tool for experimental studies on SERT.
Keywords
The serotonin transporter (SERT) , Homology modeling , template
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797435
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