Title of article
Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond
Author/Authors
Gang Liu، نويسنده , , Baolin Wu&Hongyu Zhao، نويسنده , , Bo Liu، نويسنده , , Zhili Xin، نويسنده , , Mei Liu، نويسنده , , Christi Kosogof، نويسنده , , Bruce G. Szczepankiewicz، نويسنده , , Sanyi Wang، نويسنده , , Jill E. Clampit، نويسنده , , Rebecca J. Gum، نويسنده , , Deanna L. Haasch، نويسنده , , James M. Trevillyan، نويسنده , , Hing L. Sham، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
5723
To page
5730
Abstract
The structure–activity relationships of 5,6-positions of aminopyridine carboxamide-based c-Jun N-terminal Kinase (JNK) inhibitors were explored to expand interaction with the kinase specificity and ribose-binding pockets. The syntheses of analogues and the impact of structural modification on in vitro potency and cellular activity are described.
Keywords
JNK inhibitors , Gatekeeper residue , Specificity pocket , Ribose pocket
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797461
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