Title of article
Effects of α-substitutions on structure and biological activity of anticancer chalcones
Author/Authors
Nicholas J. Lawrence، نويسنده , , Richard P. Patterson، نويسنده , , Li-Ling Ooi، نويسنده , , Darren Cook، نويسنده , , Sylvie Ducki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5844
To page
5848
Abstract
Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different α-substitutions, in particular α-fluorination, on the structure and biological activity of a series of chalcones.
Keywords
Tubulin , Fluorine , Fluorination , Anticancer , chalcone
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797487
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