Title of article
Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors
Author/Authors
Christa E. Müller-Sieburg، نويسنده , , Jamshed Iqbal، نويسنده , , Younis Baqi، نويسنده , , Herbert Zimmermann، نويسنده , , Anita R?llich، نويسنده , , Holger Stephan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5943
To page
5947
Abstract
Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.
Keywords
NTPDases , P2 receptors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797504
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