Title of article
The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)
Author/Authors
Mark Sabat، نويسنده , , John C. VanRens، نويسنده , , Matthew J. Laufersweiler، نويسنده , , Todd A. Brugel، نويسنده , , Jennifer Maier، نويسنده , , Adam Golebiowski، نويسنده , , Biswanath De، نويسنده , , Vijayasurian Easwaran، نويسنده , , Lily C. Hsieh، نويسنده , , Richard L. Walter and Alan M. Friedman، نويسنده , , Marlene J. Mekel، نويسنده , , Artem Evdokimov، نويسنده , , Michael J. Janusz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5973
To page
5977
Abstract
This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases).
Keywords
Hck , Lymphocyte specific kinase , Src family kinase , T cell , kinase , Hematopoietic cell kinase , Lck
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797510
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