Title of article
Pyridine-2-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Author/Authors
Paul S. Humphries، نويسنده , , Jonathon V. Almaden، نويسنده , , Sandra J. Barnum، نويسنده , , Thomas J. Carlson، نويسنده , , Quyen-Quyen T. Do، نويسنده , , James D. Fraser، نويسنده , , Mary Hess، نويسنده , , Young H. Kim، نويسنده , , Kathleen M. Ogilvie، نويسنده , , Shaoxian Sun، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
6116
To page
6119
Abstract
A series of novel pyridine-2-propanoic acids was synthesized. A structure–activity relationship study of these compounds led to the identification of potent dual PPARα/γ agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, compound (S)-13 was selected for further profiling.
Keywords
PPAR , Diabetes , parallel synthesis , SAR , Pharmacokinetic studies , In vivo efficacy
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797539
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