Title of article
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase
Author/Authors
Paul Bamborough، نويسنده , , John A. Christopher، نويسنده , , Geoffrey J. Cutler، نويسنده , , Marion C. Dickson، نويسنده , , Geoffrey W. Mellor، نويسنده , , James V. Morey، نويسنده , , Champa B. Patel، نويسنده , , Lisa M. Shewchuk، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
6236
To page
6240
Abstract
The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole–thiophene carbonitrile inhibitors of IKK-ε kinase is described. Compound 12e was identified with an IKK-ε enzyme potency of pIC50 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.
Keywords
IKK , IKK-? kinase inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797562
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