• Title of article

    Identification of potent and selective TACE inhibitors via the S1 pocket

  • Author/Authors

    Jeffrey S. Condon، نويسنده , , Diane Joseph-McCarthy، نويسنده , , Jeremy I. Levin، نويسنده , , Henry-Georges Lombart، نويسنده , , Frank E. Lovering، نويسنده , , LinHong Sun، نويسنده , , Weiheng Wang، نويسنده , , Weixin Xu، نويسنده , , Yuhua Zhang، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2007
  • Pages
    6
  • From page
    34
  • To page
    39
  • Abstract
    By focusing on the P1 portion of the piperidine β-sulfone ligands we identified a motif that induces selectivity and resulted in a series of TACE inhibitors that demonstrated excellent in vitro potency against isolated TACE enzyme and excellent selectivity over MMPs 1, 2, 9, 13, and 14.
  • Keywords
    inflammation , TACE , rheumatoid arthritis
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2007
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797591

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797591